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STAMPEDE M0: adding abiraterone to RT+ADT in high-risk non-met prostate cuts MFS (HR 0.53, 6yr 82% vs 69%), OS HR 0.60; enzalutamide adds nothing.
Prostate carried the day: STAMPEDE extends abiraterone's metastatic-HSPC OS benefit into high-risk M0, where 85% of pts receive definitive RT (74Gy/37fx), so this reads as systemic intensification on an RT+ADT backbone. Adding enzalutamide to abiraterone buys nothing (interaction HR 1.02, p=0.91).
read the full digest →Studies · 101
- STAMPEDE (abiraterone ± enzalutamide, high-risk non-metastatic)MFS HR 0.53 (6yr 82% vs 69%) adding abiraterone ± enzalutamide to ADT in high-risk M0; OS HR 0.60.
- TREASUREmOS numerically worse with consolidative TRT + atezo vs atezo alone (6.7 vs 13.4mo, HR 1.55 ns); SAEs 61% vs 18%, halted early for safety.
- EANO Consensus Statement on Radiation Necrosis53/57 statements reached consensus: RN in 4-30% post-brain-RT at 6-24mo; perfusion MRI + amino-acid PET to distinguish recurrence, bevacizumab if steroid-refractory.
- SBRT for Unfavorable Intermediate-Risk Prostate CancerASTRO 2024 educational round-up: 5-fraction SBRT matches conventional RT efficacy at ~1-2% bothersome toxicity; PACE-B's higher GU signal tied to an uncontoured urethra.
- HYDRAPFS non-inferior vs CFRT for isodose (HR 0.92) and dose-escalated (HR 0.94) MHFRT; dose escalation adds late G2+ bowel toxicity (OR 1.48).
- SUPREMOChest-wall RT cut 10yr chest-wall recurrence 2.5%→1.1% (HR 0.45) but no DFS/OS gain; RNI prohibited, so 'omit PMRT' overreads a chest-wall-only trial.
- ESTRO Post-op Oral Cavity CTV GuidelinesPost-op primary CTV-P = (GTV-P pre-op +10mm) composited with (surgical defect/flap +5mm); first consensus method to standardize oral-cavity PORT delineation.
- ARS AUC: Intraprostatic Recurrence After RTConsensus AUC: PSMA PET + mpMRI + confirmatory biopsy before salvage reirradiation; short classic ADT preferred over ARSI, most regimens ≤6 fractions.
- 10-yr SBRT for Prostate Cancer (Nonrandomized Trial)10-yr RFS 90% (94% LR, 86% IR), OS 84%, late G3+ GI/GU ≤1.5% after 40Gy/5fx prostate SBRT, no ADT.
- NRG-GU005Bowel QoL MCID decline 35% vs 44% (p=0.034) favoring 5-fx SBRT; but DFS superiority not met (HR 1.38, futility) vs MH-IMRT.
- SUPREMO10-yr OS 81.4% vs 81.9% (HR 1.04, p=0.80): no survival benefit from post-mastectomy chest-wall RT in intermediate-risk disease.
- EORTC 22033-26033/NCIC-CTG/TROG/MRC-CTUNo PFS/OS difference between RT (28×1.8 Gy) and dose-dense TMZ monotherapy in high-risk WHO grade 2 glioma; molecular subtype drives outcome.