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ENZARAD: MFS primary negative (HR 0.88, p=0.34); enzalutamide benefit isolated to cN1 (HR 0.43) and planned-pelvic-RT (HR 0.47) subgroups, hypothesis-generating.
Prostate carries the day's only data: ENZARAD's 24-mo enzalutamide added to EBRT+ADT misses its MFS primary (HR 0.88, p=0.34), but the signal concentrates in cN1 (MFS HR 0.43) and planned-pelvic-RT (HR 0.47) subgroups, both risk-confounded and hypothesis-generating.
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- ENZARAD (ANZUP 1303)Primary MFS endpoint negative (HR 0.88, p=0.34); enzalutamide benefit concentrated in cN1 (HR 0.43) and planned-pelvic-RT (HR 0.47) subgroups.
- ARS Appropriate Use Criteria: Locoregionally Recurrent Rectal CancerMargin-negative (R0) resection drives survival and local control; preop RT or systemic therapy downsizes tumor to improve R0 likelihood.
- PRIMARY2PSMA-PET avoided biopsy in 49% while csPCa detection (12% vs 16%, diff −3.7%, 95% CI −8.9 to 1.5) was non-inferior to systematic biopsy.
- INDIBLADE2yr bladder-intact EFS 78% (67-90), OS 96% (91-100) with induction ipi/nivo then chemoRT in cT2-4aN0-2 MIBC.
- DOREMY5-yr LRFS 97.4% with dose-reduced 36 Gy/18fx preop RT in myxoid liposarcoma, median f/u 66mo.
- REVELUTIONAdjusted total plaque volume +68.9mm³ with leuprolide vs relugolix at 12mo, GnRH agonist accelerating coronary atherosclerosis.
- KEYNOTE-689 vs NIVOPOSTOP3y DFS ~63% vs 53% adding adjuvant nivo to post-op chemoRT (NIVOPOSTOP); perioperative pembro hits EFS (KEYNOTE-689) in resectable LA-HNSCC.
- GEC-ESTRO APBI Patient Selection Guidelines (2026 Update)Updated selection expands low-risk APBI to age >40, ≤30mm, pN0/pN1mi, all histologies, DCIS at ≥2mm margins; BRCA/TNBC/age<40/EIC/extensive-LVI contraindicated.
- ORIOLESABR cut 6-mo progression to 19% vs 61% (P=.005) and improved mPFS (NR vs 5.8mo, HR 0.30) in oligomet HSPC.
- ARTOPSA response 92% vs 68.3% (OR 5.34) and PFS HR 0.35 adding SBRT to abiraterone in oligomet CRPC.
- WOLVERINEMDT+SOC cut PFS events vs SOC alone (HR 0.44, p<0.0001) across 6 oligomet prostate RCTs; OS HR 0.63 (p=0.051) not significant.
- RADIOSAcPFS 32.2 vs 15.1mo, HR 0.43 (0.26-0.72), p=0.001 adding 6mo ADT to metastasis-directed SBRT in oligorecurrent HSPC.